Chad Michael Murray portrays Lucas Scott, the son that Dan never claimed. This led to Keith being the father figure in his life. He and Nathan start out as enemies but bond as Marafiki and as brothers as the onyesha progresses. Lucas' best friend is Haley and he has been a romantic interest for both Peyton and Brooke. Lucas has a serious moyo condition, hypertrophic cardiomyopathy (HCM) which he concealed for a long time. Aside from basketball, his greatest passion is literature and nukuu from the vitabu he reads are used on the show. In Season Five, he is a successful writer and head coach of the Ravens mpira wa kikapu team. He was in a relationship with his editor, Lindsey Strauss but conflicted kwa his feelings for former upendo Peyton, causing Lindsey to leave him at the altar. In the season finale, he asks one of Brooke, Peyton au Lindsey to marry him. It is revealed he chooses Peyton.
James Lafferty portrays Nathan Scott, the son that Dan did claim, although his relationships with both his parents are strained at the best of times. Nathan marries Haley in Season One and they renew their vows in Season Three, and later becomes a father to James Lucas "Jamie" Scott in Season Four. In Season One, he and Lucas start out as enemies, but bond as Marafiki and brothers as the onyesha progresses. Nathan is the nyota player of the Ravens and is named "Most Valuable Player" in Season Four. Also, in Season Four, he is investigated for shaving points. He loses his mpira wa kikapu scholarship to Duke chuo kikuu, chuo kikuu cha because he admits to shaving points in two games. mpira wa kikapu has always been his greatest passion and he sees it as his "way out", but in Season Five, a fight leaves Nathan near-paralyzed and his dreams shattered, though he later regains the use of his legs and slowly starts to make a comeback in basketball.
Hilarie burton portrays Peyton Sawyer, whose two greatest passions in life are muziki and art; she is an expert in the punk rock genre and uses her art to express the issues that play out in her life. Brooke Davis is her best friend while also having Haley to talk to. In season Two, she discovers that she is actually adopted. She has never met her biological father although she has met his son, her half-brother, Derek. After getting to know her birth mother, Ellie, she loses her to breast cancer. In Season Four, Peyton decides to act on her feelings for Lucas and they begin a relationship. This relationship has ended between seasons Four and Five and in Season Five, a lonely Peyton is working for a record company in LA. She and Brooke decide return to mti Hill, where she starts her own record label, Red Bedroom Records, and battles her feelings for Lucas again. Lucas asks her to marry him and she agrees.
Bethany Joy Galeotti portrays Haley James Scott, Lucas' best friend, Nathan's wife and Jamie's mother. She is an extremely intelligent woman with high morals. She marries Nathan in Season One and they renew their vows in Season Three, while Season Four sees her give birth to her son, Jamie. In Season Five, as well as balancing roles as a wife and mother, she is an English teacher at mti kilima High and is also seen to be planning a musical comeback. She is good Marafiki with Peyton, Brooke, Skills, Mouth and Lindsey. In season five she tries very hard to help with a difficult student, Quentin. Haley had a fling with Chris Keller, angering Nathan but the two rekindled their love. Haley is not very good at sports, seeing as she almost failed gym in season one.
Sophia kichaka portrays Brooke Davis, captain of the cheerleading squad. She is Peyton's best friend throughout most of the series. Feisty and flirtatious, she dated Lucas twice but neither time their relationship works out. In Season Three, she creates a clothing line, "Clothes Over Bros". In Season Five, Brooke has made Clothes Over Bros a household name, but despite her success, she is unhappy in her personal life so she and Peyton return to mti kilima where Brooke turns a now-closed Karen's Café into a Clothes Over Bros store. She then reveals her desire to have a baby and looks after Baby Angie, who is in the US for moyo surgery. Brooke is devastated when the time comes for Angie to return to her nyumbani country.
Paul Johansson portrays Dan Scott, a once great mpira wa kikapu player, who is father to both Nathan and Lucas, although he never wanted anything to do with the latter. After his marriage to Deb crumbles and she and Nathan try to rid themselves of him, Dan's evil comes to the forefront. After Dan finds Deb sleeping with his brother, Keith, a war begins between the two brothers, culminating with Dan fatally shooting his brother in Season Three, believing that Keith had set his car dealership alight. After discovering that Deb was actually behind the fire, Dan tried to make amends kwa supporting Karen through her pregnancy and started to turn over a new leaf. However, after Lucas discovers he is Keith's murderer, he is placed in jail. Four years later, he is granted parole and tries to redeem himself to his family, because he is dying of HCM. In the season finale, he is knocked down kwa a car moments before his beeper goes off to inform him that he is ready for his moyo transplant. It is revealed that in the new season Carrie (the crazy lady who was once Jamie's nanny) was the one who hit Dan in the car accident. She intends to use him to get Jamie. After she gets him she intends to kill Dan.
Barry Corbin portrays Coach Brian "Whitey" Durham (S1-S4), the Ravens coach for thirty-five years, retiring in Season Four. He and Dan never saw eye-to-eye and often bickered over their differing opinions on the team. Whitey often laments the death of his wife, Camilla, and the fact that he didn't spend zaidi time with her while she was alive. He retires after the Ravens finally win him his much-coveted State Championship title in Season Four but later takes a coaching position in a college three hours away from mti Hill, so that Nathan has the chance to play college basketball.
Craig Sheffer portrays Keith Scott (S1-S3), Dan's older, kinder, under-achieving brother. After Dan chose Deb over Karen, Keith helped Karen to raise Lucas (acting as a surrogate father to him) and fell in upendo with her but they only got together in Season Three. He had a recurring drink problem and an ongoing rivalry with his brother which involved him sleeping with Deb and Dan paying Jules to seduce Keith and then dump him to get back at Keith for this. When Dan mistook him for the one who tried to kill him in the dealership fire, he shot him after the siege at mti kilima High, killing him instantly. Since his death, Karen has aliyopewa birth to Keith's daughter, Lily. Keith has been haunting Dan as a teen and as an adult ghost, but later forgives him for what he has done. He has guided his nephews as a sort of Guardian Angel throughout Season Four.
Moira Kelly portrays Karen Roe (S1-S4), Lucas' mother. Dan abandoned her after she became pregnant in High School and with a lot of help from Dan's brother (and in later years, Karen's lover and father of her sekunde child) Keith, Karen raised Lucas alone. Karen is devastated kwa Keith's death in Season Three. In Season Four, she gets close to Dan again before learning that he was the one who killed Keith and has aliyopewa birth to Keith's daughter, whom she names Lily Roe Scott. In Season Five, Karen is traveling the world with Lily and when she returns for Lucas' wedding, she is accompanied kwa Andy Hargrove.
Barbara Alyn Woods portrays Deb Scott, Dan's neurotic ex-wife and Nathan's mother. Married to Dan for seventeen years, she eventually divorces him in Season Three, her hatred of him driving her to attempt to kill him at one point. Deb battles a pill addiction in Season Two and again in Season Four, but overcomes it for good the sekunde time. In Season Five, she returns after an unexplained absence to be Jamie's nanny and begins a surprising and secretive sexual relationship with Skills.
Lee Norris portrays Marvin "Mouth" McFadden, one of Lucas' oldest friends, originating from the River Court. He is somewhat unlucky in love, being the victim of Brooke's unrequited upendo in Season Two, being dumped kwa Erica when she becomes maarufu and falling for Rachel, only to get sidelined for the older Cooper. GiGi, his co-sports announcer, has also broken up with him after only seeing him for a few weeks and Shelly Simon runs out on him after he loses his virginity to her. In Season Five, he has a fling with his boss, Alice, before finally settling down with Millicent. Mouth becomes a sports commentator in Season Five, having commentated at the Ravens' games throughout High School but quits his job in the season finale.
Antwon Tanner portrays Antwon "Skills" Taylor, one of Lucas' oldest friends, originating from the River Court. He takes on a zaidi prominent role in Season Four when he fills Lucas' vacancy on the Ravens. In Season Five, he becomes the assistant Head Coach of The Ravens mpira wa kikapu team and lives with Mouth, junk, taka and Fergie. He and his High School girlfriend Bevin Mirskey are no longer together in Season Five and Skills begins a sexual relationship with Deb after meeting each other online.
Danneel Harris portrays Rachel Gatina, who moves to mti kilima in Season Three. After joining the cheerleading squad, she instantly clashes with Brooke as she pursues Lucas, although Brooke and Rachel later become friends. Rachel gets close to Mouth but sidelines him for Cooper, who dumps Rachel when he finds out she lied about her true age. After Nathan and Haley's wedding, Cooper and Rachel have an altercation in the limo which causes it to veer off the Molina Bridge and into the water. Nathan rescues Rachel and she develops a crush on him but backs off when she discovers that Haley is pregnant. Rachel takes the fall for a calculus exam she aliiba with Brooke and, to protect her new friend, is expelled from mti kilima High. In Season Five, Rachel is a former employee of Brooke's and a heroin addict who takes an overdose after being fired kwa her friend. Brooke brings Rachel back to mti kilima to help get her life back on track but Rachel leaves again, taking a load of Brooke's cash with her, after an encounter with Victoria.
Jackson Brundage portrays James "Jamie" Scott, the son of Nathan and Haley's, born at the end of Season Four. In the fifth season, he is four years old and the center of attention with his parents, godparents Lucas and Brooke, and the rest of his parents' friends. He is abducted kwa his former nanny Carrie in the show's one hundreth episode and after being rescued kwa Dan, Jamie becomes determined to get to know his grandfather, despite his parents' reservations.
Lisa Goldstein portrays Millicent Huxtable, Brooke's assistant for Clothes over Bros. She is involved in a romantic relationship with Marvin "Mouth" McFadden. She moves to Omaha with him at the beginning of Season 6, which aired September 1, 2008