Two Enterprises predate the United Federation of Planets.
XCV 330Registry: USS Enterprise (XCV 330)
Service: circa 2130s
This USS Enterprise (XCV 330) appears in nyota Trek: The Motion Picture among a series of illustrations depicting ships named Enterprise. The 1979 nyota Trek Spaceflight Chronology describes this "first interstellar liner" as a Declaration-class ship launched in 2123.
NX-01Registry: Enterprise (NX-01)
Service: 2151 – 2161
Captain: Jonathan Archer (Scott Bakula)
The United Earth Starfleet's Enterprise is the main setting of nyota Trek: Enterprise.
 The Original Series era
Three ships named USS Enterprise are featured in the original nyota Trek televisheni series and the first through seventh nyota Trek films.
NCC-1701Registry: USS Enterprise (NCC-1701)
Service: 2245 – 2285
Captains: Robert April (James Doohan, Gene Roddenberry), Christopher pike (Jeffrey Hunter), James T. Kirk (William Shatner), Willard Decker (Stephen Collins) (refit), Spock (Leonard Nimoy) (refit)
The Federation's first Enterprise is the main setting of the original nyota Trek series (1966–1969) and The Animated Series (1973–74). A refitted Enterprise appears in nyota Trek: The Motion Picture (1979) and nyota Trek II: The Wrath of Khan (1982), before being destroyed in nyota Trek III: The tafuta for Spock (1984).
NCC-1701-ARegistry: USS Enterprise (NCC-1701-A)
Class: Constitution refit
Service: 2286 – 2293
Captain: James T. Kirk (William Shatner)
This ship first appears at the end of nyota Trek IV: The Voyage nyumbani (1986) and is the main setting of nyota Trek V: The Final Frontier (1988) and nyota Trek VI: The Undiscovered Country (1991). The ship is ordered decommissioned at the end of The Undiscovered Country. Paperwork included with the model kit indicated the ship was mothballed at the Memory Alpha ship museum, and William Shatner's novel The Ashes of Eden (1996) depicts the Enterprise-A's removal from the mothball fleet before being destroyed defending the planet Chal.
NCC-1701-BRegistry: USS Enterprise (NCC-1701-B)
Class: Excelsior refit
Service: 2293 –
Captain: John Harriman (Alan Ruck)
Launched at the start of nyota Trek Generations (1994). James T. Kirk goes missing during the ship's maiden voyage. According to nyota Trek novels, Demora Sulu becomes captain after Harriman.
 The inayofuata Generation era
Three ships named Enterprise are featured in nyota Trek: The inayofuata Generation and four TNG-era films.
NCC-1701-CRegistry: USS Enterprise (NCC-1701-C)
Service: 2332 – 2344
Captain: Rachel Garrett (Tricia O'Neil)
This ship appears in the inayofuata Generation episode "Yesterday's Enterprise" (1990). It was destroyed attempting to defend the Klingon outpost Narendra III from Romulan attack. Survivors included Tasha Yar (Denise Crosby), whose alternate timeline version from "Yesterday's Enterprise" travels with the ship back in time to the battle over Narendra III. The actions of the Enterprise-C's crew became a catalyst for the alliance between the Federation and the Klingon Empire.
NCC-1701-DRegistry: USS Enterprise (NCC-1701-D)
Service: 2363 – 2371
Captains: Jean-Luc Picard (Patrick Stewart), William Riker (Jonathan Frakes), Edward Jellico (Ronny Cox)
The main setting of nyota Trek: The inayofuata Generation (1987–1994). The Enterprise was Lost in 2371 after an attack kwa a renegade Klingon Bird-of-Prey (commanded kwa the Duras sisters) caused extensive damage, leading to a warp core breach. Although the saucer section was safely separated before the breach, the shock wave from the explosion caused it to crash land on Veridian III. The ship was not salvageable.
NCC-1701-ERegistry: USS Enterprise (NCC-1701-E)
Service: 2372 – Active (as of 2380)
Captain: Jean-Luc Picard
The main setting for the films nyota Trek: First Contact (1996), nyota Trek: Insurrection (1998), and nyota Trek Nemesis (2002).
 Alternate timelines
Enterprise DRegistry: USS Enterprise (NCC-1701-D)
Class: Galaxy Refit
Captain: Admiral William T. Riker
In "All Good Things...", the final episode of nyota Trek: The inayofuata Generation, the Enterprise-D was shown in an alternate future where it had been refitted to include a third nacelle, cloaking ability and large phaser cannons on the saucer section.
Enterprise JRegistry: USS Enterprise (NCC-1701-J)
Service: 26th Century
The "Azati Prime" episode of nyota Trek: Enterprise involves time travel and features a scene in which the Enterprise-J appears. The Enterprise-J operates in one possible version of the 26th century. 
The inayofuata Generation novel Imzadi shows an alternate timeline Enterprise-F commanded kwa Commodore Data in the 25th century. War of the Prophets, one of the Millennium trilogy of nyota Trek novels kwa Judith and Garfield Reeves-Stevens, presents an alternate universe Enterprise-F destroyed in the 24th century.
The nyota Trek shabiki production nyota Trek: Of Gods and Men includes a recreation of the original series' Constitution-class Enterprise designated NCC-1701-M.
 Mirror Universe
The Mirror Universe first appeared in the original series as reality where a militaristic empire exists in place of the regular universe's United Federation of Planets. Subsequent episodes have shown that the divergence at least predates the Moon landing, with licensed novels putting the divergence before Shakespeare, au even classic Greek literature.
ISS Enterprise (NX-01)Registry: ISS Enterprise (NX-01)
Captains: Maximilian Forrest (Vaughn Armstrong), Jonathan Archer
The nyota Trek: Enterprise episode "In a Mirror, Darkly" features a Mirror Universe version of the NX-01 Enterprise. This ship is equipped with a cloaking device, deflector shields, a trekta beam, a prototype Agony Booth, and different exterior markings. It is commanded kwa Captain Maximilian Forrest, although for a brief time his first officer, Commander Jonathan Archer, takes command following a mutiny. This Enterprise is destroyed kwa the Tholians.
Remastered ISS Enterprise (NCC-1701)Registry: ISS Enterprise (NCC-1701)
Captains: Christopher Pike, James T. Kirk, Spock
A Mirror Universe Enterprise appears in the original nyota Trek episode "Mirror, Mirror". The ship is equipped with an agony booth and the mirror Captain Kirk's deadly Tantalus device. The ISS Enterprise was originally the same shooting model as the regular Enterprise. The remastered version of "Mirror, Mirror" includes a CGI version of Enterprise with "ISS" markings on the hull and minor physical differences from USS Enterprise, such as a larger deflector dish, a taller bridge, and altered nacelle details.
Registry: ISS Enterprise (ICC-1701-D)
The inayofuata Generation novel Dark Mirror describes an alternate timeline Enterprise-D staffed kwa Mirror Universe versions of Captain Picard and his crew.
 Altered reality timeline
The 2009 nyota Trek film takes place in an altered reality created when the Romulan character Nero traveled through time via a black hole. It is also the expected setting of the inayofuata film in the series. Registry: USS Enterprise (NCC-1701)
Captains: Christopher pike (Bruce Greenwood), Spock (Zachary Quinto), James T. Kirk (Chris Pine)