Yuki Cross's earliest memory is of being attacked kwa a vampire and saved kwa Kaname Kuran, also a vampire. Ten years later, Yuki and a vampire hunter, Zero Kiryu attend kuvuka, msalaba Academy as school guardians protecting the "Day Class" and the "Night Class" from each other to keep Wanyonya damu secret. The story follows Yuki's discovery that her childhood friend, Zero, has spent the last four years trying to fight his transformation into a vampire, and he has finally succumbed. Yuki struggles to help Zero fight his bloodlust and to recover her own Lost memories, while suspecting that Kaname knows zaidi than he is saying.

When his uncle, Rido Kuran, returns to kill Yuki, Kaname is forced to reveal her secret kwa biting Yuki and awakening her true nature as a vampire, returning her memories of being Yuki Kuran, his younger sister. Rido is killed kwa Zero and Yuki while Kaname faces and destroys Rido's allies, the Vampire Council, revealing himself to be one of the original Wanyonya damu and the founder of the Kuran clan. Yuki and Zero part as enemies after Zero reveals he intends to end everything, kwa killing all purebloods, even her. Yuki leaves with Kaname and they return to the Kuran family home. The story restarts a mwaka later with Yuki's dealing with vampire society and new enemies, such as Sara Shirabuki.