Well it really depends on which show/movie your looking at , Im Twilight its because the Wanyonya damu kill people and the Mbwa mwitu loups are the protectors but in vampire diares its because there both uncontrollable things so really it depends but form all the fiction things i have read over the years its zaidi of just a mortal enemy type thing that there naturaly born to kill each other
Wanyonya damu and werewolfes are enemies because they smell to each other but if wewe have read the vitabu wewe know that if they try to get along they can.
The mtu-bweha came into existence as protectors of their tribe. Then a pair of Wanyonya damu attacked the tribe and another neighbouring tribe. Those Wanyonya damu were the most dangerous enemies the Mbwa mwitu loups had ever fought. They've been natural enemies ever since.