inayopendelewa Half-Human and Half-Demon/monster/Animal/spirit/god/whatever

I'm not sure if he's exactly half human, but mbwa mwitu from Blood Lad is only half werewolf.
(He might be half human because his mother was living in the human world...and if I remember correctly, demons can't last very long in the human world because they rely on magic au whatever it's actually called in that and the human world doesn't have much)
And if not, Centorea Shianus from Monster Musume is half human, because her father was a human and her mother was a centaur.

I think Yuki Sohma counts, he's cursed with the spirit of the panya from the Zodiac and transforms into one